Aging is a biological process that no one can avoid. Ideally, growing old should be a time to relax and enjoy the fruits of your labor. Aging also has a darker side, however, often linked to disease.

Aging is the primary risk factor for numerous life-threatening diseases and has long been a central focus of biological research. Epigenetic reprogramming, a process that can modulate cell fate and ...

Life runs on information. In living systems, that information takes two main forms: the genome and the epigenome. The genome stays mostly stable. The epigenome, however, constantly shifts, shaped by ...

Life relies on the storage and transmission of information. In complex organisms, this information exists in two primary forms: the genome and the epigenome. While genetic information remains largely ...

That inevitability of growing older might not be as fixed as we once believed. Emerging research has begun challenging our most fundamental assumptions about aging, revealing that cellular ...

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and aging are locked in a vicious circle: senescence of liver cells accelerates fat accumulation, inflammation and ...

FAS, fatty acid synthase; FATP, fatty acid transporter protein; GPCR, G protein-coupled receptor; LPC, lysophosphatidylcholine; LXR, liver X receptor; PPARγ, peroxisome proliferator-activated receptor ...

The field of immunogerontology investigates age-associated declines in immune function, particularly focusing on the reduced lymphoid potential of ...

Aging has long been seen as a natural, unstoppable part of life. From the moment we're born, our bodies transform — first through growth, then through gradual decline. Over time, stamina wanes, ...

Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...