Most prostate cancers rely on male sex hormones, known as androgens, to grow. As a result, standard treatment focuses on ...

Prostate cancer, especially in advanced stages such as castration-resistant prostate cancer, is challenging to treat. Traditional therapies targeting androgen receptor (AR) signaling have limited ...

We analyzed 8,019 prostate tumors using DNA/RNA sequencing (Caris Life Sciences), classifying them into four molecular subtypes (AR+/NE–, AR–/NE+, AR+/NE+, AR–/NE–). Genomic alterations, cell surface ...

If a prostate cancer cell were a car, the androgen receptor (AR) would be part of its ignition system, enabling cancer cells to respond to hormonal signals that drive growth. For decades, therapies ...