Researchers at the Josep Carreras Leukaemia Research Institute propose a new view of cancer based on spatial hallmark ecosystems and its evolution during cancer progression. This conceptual framework ...

Mesothelin-targeted CAR-NKT cells leveraged three recognition mechanisms, potentially limiting antigen escape and immunoediting compared with single-pathway CAR-T constructs. Complete tumor ...

In the same vein as weather forecast models that predict developing storms, researchers have now developed a method to predict the cell activity in tissues over time. The new software combines ...

Commercialization ready compound supports a new method of generating highly functional human CAR-T cells for treating infectious diseases and cancer In experimental models, human CAR-T cells ...

Finding an effective treatment for osteosarcoma, the most common type of bone cancer in children and young adults, has ...

Immunotherapy has transformed cancer treatment by harnessing the body's own immune system to fight disease. But many engineered immune cells lose strength quickly after they enter the body, especially ...

Cancer cell-derived small extracellular vesicles (sEVs) can travel from distant tumors through the bloodstream and kidneys ...

A triple drug approach that blocks the KRAS pathway at three points eliminated pancreatic tumors and prevented resistance in ...

GigaTIME can transform routine pathology slides into detailed spatial proteomics data -- a high-resolution map of proteins -- ...

Scientists looking for new ways to tackle hard-to-treat breast cancers turned to an unexpected source: Munronia henryi, a plant known for producing limonoids, a family of complex natural compounds ...