Cells in the human body accumulate cancer-promoting mutations throughout their lifespan, yet these mutations rarely drive tumour formation. Tumours in a given tissue usually originate from a specific ...

The review emphasizes how breakthroughs in understanding the molecular mechanisms of cell cycle regulation have paved the way for the development of targeted anti-cancer agents. Notably, inhibitors of ...

Six epigenetic features define the new Epigenetic Hallmarks of Cancer, an add-on to the widely accepted Hallmarks of Cancer. Scientists concluded that malignant transformation requires some degree of ...

“What is a tumour?” This is the fundamental question to answer if we want to treat cancer effectively. Our vision of cancer and tumours has been evolving with time, from the simplistic bunch of ...

Cancer researchers have long treated genetic chaos and epigenetic rewiring as separate engines of disease, two parallel hallmarks that help tumors grow, spread, and resist treatment. Now a new wave of ...

Researchers from the University of Seville have participated in research to identify the molecular details of the regulation of an enzyme essential for sugar metabolism and closely linked to cell ...