BMJ Open

Changes in the epidemiology of heart failure in the decade 2014–2023: insights from the AQUORE retrospective cohort study

Objective Heart failure (HF) is a major public health issue due to its high morbidity, mortality and healthcare burden. This ...
ascopubs.org

Using Dose-Escalation and -Expansion Cohort Study as Pivotal Trial for Targeted Anticancer Drug Approval

BRCA1-Associated Protein 1 and Enhancer of Zeste Homolog 2: Pathway Interaction and Therapeutic Intervention in Breast Cancer, Mesothelioma, and Lymphoma Early-phase clinical trials (EPCTs) have been ...
Nature

Case-Cohort Study Designs and Semiparametric Models

Case-cohort study designs represent a cost-effective and efficient strategy for analysing time-to-event data, particularly when the event of interest is rare. By selecting a random subcohort along ...
BMJ

Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations ...

Objective To examine and summarise evidence from meta-analyses of cohort studies that evaluated the predictive associations between baseline cardiorespiratory fitness (CRF) and health outcomes among ...
BMJ Open

Life expectancy gains across US states between 1941 and 2000: a cohort study

Objectives We use new data and robust methods to estimate mortality levels and trends for US states and Washington DC and ...
BMJ

Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies

6 Health and Social Research Center, Universidad de Castilla La-Mancha, Cuenca, Spain Objective To examine the predictive validity of field-based muscular strength tests in relation to incident ...