In a study published in the journal Immunity, Carlene L. Zindl, Ph.D., and Casey T. Weaver, M.D., of the University of Alabama at Birmingham Department of Pathology show how two types of immune cells ...

Intestinal epithelial cells line the inner wall of the gut, creating a barrier to dangerous bacteria like enteropathogenic E. coli that seek to attach and efface that barrier, causing diarrhea. Such ...

Normal human colonic crypts are pictured. SMOC-2 expression (red) in the colonic stem cells demonstrates that these cells are localized in the bottoms of the crypts. Bars represent 100 micrometers ...

I am currently a doctoral trainee in Dr. Sandy Markowitz’s lab. One focus of the Markowitz lab is to investigate how inhibitors of 15-prostaglandin dehydrogenase (15-PGDH) resolve inflammation and ...

Focal active colitis (FAC) is when a specific type of white blood cell enters tiny structures in the colon wall, causing inflammation. Various conditions can lead to FAC, such as Crohn’s disease.

The study, “A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts,” was published in Immunity. The team, led by Carlene L. Zindl, Ph.D., found that IL-22 ...

Intestinal epithelial cells line the inner wall of the gut, creating a barrier to dangerous bacteria like enteropathogenic E. coli that seek to attach and efface that barrier, causing diarrhea. Such ...