Recently, pyrogen has been shown to be released from normal human blood leukocytes after stimulation by endotoxin or by phagocytosis of heat-killed bacteria. 4 When injected intravenously in rabbits, ...

THE pathogenesis of endotoxin fever has been much elucidated since the observation of the appearance in the serum of a fever-producing substance (endogenous pyrogen) after endotoxin 1. The transient ...

SUBSTANCES capable of producing fever in normal recipients (the so-called endogenous pyrogens) appear in the serum of experimental animals during fever due to bacterial endotoxin, influenza virus and ...