One of the first intracellular kinases to be explicated as a protooncogene was c-Src, an upstream mediator of both the PI 3-K and MAPK pathways. The amplified c-Src activity has been implicated in ...

COUP-TFs comprise a family of highly conserved transcription factors within the steroid-thyroid-retinoic acid super-family of nuclear receptors. The high degree of conservation among the COUP-TFs ...

Insulin binding to Golgi and plasmalemma fractions from the liver of obese (ob/ob and db/db) and lean control mice was studied. The specificity of binding in Golgi fractions (Golgi vesicles and Golgi ...

The LAT Signalosome The models summarized in the Antigen Discrimination and Intracellular Receptor Phopshorylation sections describe T-cell activation up to the point of ZAP-70 binding to the ...

Signal transduction is the term for the process which causes chemical and physical signals to be transmitted within a cell as a series of molecular events. The most common signal transduction process ...