Among patients with low-stage, MYCN-amplified neuroblastoma, outcomes of patients with hyperdiploid tumors were statistically, significantly better than those with diploid tumors. The data suggest ...

The Myc family of transcription factors, including Myc, N-Myc, and L-Myc, bind DNA at specific sequences and regulate gene expression by binding to enhancer-box (E-Box) sequences via dimerization with ...

Corresponding author Jun Yang, MD, PhD, (left) and co-first authors Jie Fang, PhD, (center) and Shivendra Singh, PhD (right), identified a window of opportunity to treat high-risk MYCN-amplified ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality. Targeting oncogenes and their interactive partners is an effective ...

Family, friends and a football club are among those rallying round to raise funds for a little girl diagnosed with an ...

A particularly slippery transcription factor, MYCN, is thought to stimulate tumor cell growth and proliferation through amplification of gene transcription. MYCN and like proteins are slippery in the ...

Researchers at the University Medicine Halle have identified a novel, feasibly druggable pathway that is involved in initiating neuroblastoma tumor growth. The scientists’ studies in human ...

Researchers have identified new variations in neuroblastoma that could lead to a more accurate prognosis and better-targeted treatments for this devastating childhood cancer. A study reveals three new ...

Neuroblastoma cells harbor a pattern of chromosomal aberrations that include chromosomes 1p and 11q deletions and 2p and 17q gains, as well as MYCN gene amplification with MYC overexpression. Recent ...