Callio Therapeutics Doses First Patient in Phase I Clinical Trial of Dual-Payload ADC CLIO-8221 in Advanced HER2-Expressing Solid Tumors

Callio Therapeutics is actively developing a pipeline of promising dual-payload ADCs featuring rationally designed payload combinations for hard-to-treat tumors CLIO-8221 is the first program from ...
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Phase I trial finds breast cancer vaccine triggers an immune response and is safe

Cleveland Clinic researchers are presenting final Phase I data from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease ...

Avalyn initiates Phase II AURA trial for idiopathic pulmonary fibrosis

Avalyn has initiated the AURA Phase II clinical trial assessing the efficacy and safety of AP02, inhaled nintedanib delivered ...
GEN

Schrödinger Halts Cancer Drug Program after Two Patients Die in Phase I Trial

Schrödinger has halted development of its cancer-fighting candidate SGR-2921 after two patients treated with the cell division cycle 7 (CDC7) inhibitor died in a Phase I trial. The trial (NCT05961839) ...
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Recurrent and Refractory Ewing Sarcoma Phase I/II Trials: Current Perspective From the Euro-Ewing Consortium

Immune Checkpoint Inhibitors in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor–Resistant Chemotherapy-Naïve Advanced Non–Small Cell Lung Cancer: A Meta-Analysis Based on Eight Randomized ...
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Isosceles Pharmaceuticals Announces Acceptance of IPI201 for Phase I First-in-Human Clinical Trial

Novel intravenous anti-inflammatory candidate advances to Phase I evaluation to assess safety, tolerability, and pharmacokinetics. WILMINGTON, NC, UNITED STATES ...