A new study shows p62-mediated Mallory-Denk body formation is an adaptive, protective response to alcohol-induced liver ...

Liquid-liquid phase separation is not a precursor to formation of amyloid fibrils, a pathological hallmark of Parkinson's disease, shows study. Rather, the formation of protein into liquid droplets ...

Alcohol-associated liver disease (ALD) remains a leading cause of cirrhosis and liver-related mortality worldwide, with few effective therapies.

Recent research demonstrates that protein phase separation (PPS) is widely present in cells and drives a variety of important biological functions. Protein phase separation at the wrong place or time ...

A collection of Articles with associated content and a Q&A describes a selection of factors that influence biomolecular phase separation. They explore advances in methodologies for studying this ...

New York and Cambridge, UK -- Recent research demonstrates that protein phase separation (PPS) is widely present in cells and drives a variety of important biological functions. Protein phase ...

Protein misfolding and aggregation are key features observed in numerous neurodegenerative conditions, such as Alzheimer's and Parkinson's disease. The oligomers formed during the aggregation process ...

Tubulin acts as a master regulator, preventing Tau and alpha-synuclein from forming toxic clumps in Alzheimer's and Parkinson's.