Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy);(2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 ...

Disrupting the AID/RAD51 axis protects nonobese diabetic mice from type 1 diabetes, report scientists. Researchers at The Jackson Laboratory, Cyteir Therapeutics and collaborating institutions have ...

Researchers from Osaka University demonstrate how DNA replication machinery plays an important role in the choice of recombination pathway at the centromeres of chromosomes to limit harmful gross ...

Mladenov, E., Kalev, P. and Anachkova, B. The Complexity of Double-Strand Break Ends is a Factor in the Repair Pathway Choice. Radiat. Res. 171, 397-404 (2009). The repair of double-strand breaks in ...

Researchers have identified two new genes in which mutations can interfere with a cell's ability to remove misplaced links between DNA strands, and, as a result, cause a rare genetic disorder known as ...

The discovery of a major role for homologous recombination as a DNA repair pathway implied that cell mutants, isolated on the basis of sensitivity to certain DNA-damaging agents, could have homologous ...

LEXINGTON, Mass., July 7, 2020 Cyteir Therapeutics, a leader in the discovery and development of next-generation synthetic lethal therapies for cancer, today announced continued progress in their ...

BRCA1 and BRCA2 genes encode for proteins that have important roles in DNA repair and act as tumor suppressors. Though there are differences in the sequence and structure of the proteins produced by ...