Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide. A growing body of evidence identifies endothelial dysfunction as ...

The RAS in obese patients can contribute to progression of insulin resistance to diabetes and endothelial dysfunction to atherosclerosis. Blockade of the RAS, including the RAS in adipose tissue, is ...

The renin–angiotensin system (RAS) orchestrates cardiovascular and fluid homeostasis through a cascade of peptide hormones and receptors. In pregnancy, adaptive up-regulation of renin release, ...

A recent New England Journal of Medicine article proposed "endothelialitis" as the unifying mechanism for the widespread pathology of COVID-19. In a prior Medscape interview, Medscape contributor ...

A polygenic risk score (PRS) based on genes associated with endothelial cell function identifies patients at a higher risk of coronary artery disease, according to a new study. The risk score, which ...

The glycocalyx emerges as an active endothelial system whose structure, metabolism, and shear-dependent regulation integrate mechanical forces with vascular signaling. Disruption of this system ...

In patients with diabetes, ACE inhibitors and ARBs are preferred drugs for the treatment of hypertension and the prevention of cardiovascular events. 17,40 These drugs reduce the cardiovascular ...