Scientists have determined the three-dimensional structure of the target of the first-line anti-tuberculosis drug rifampin. They have also discovered a new class of potential anti-tuberculosis drugs ...

A research group is studying disease resistance in tuberculosis. The group has described the structure of a regulator that controls the expression of a pump that removes toxins from the bacteria.

Besides their normal role, pump overexpression confers drug resistance. Knowing the structure is a step to disabling the pumps with inhibitors BIRMINGHAM, Ala. – Tuberculosis is the world’s leading ...

Rutgers University scientists have determined the three-dimensional structure of the target of the first-line anti-tuberculosis drug rifampin. They have also discovered a new class of potential ...

Tuberculosis is one of the top ten causes of death worldwide, infecting about one-quarter of the world's population. Although it is treatable, the rise of multidrug-resistant tuberculosis poses a ...

AMES, Iowa – Edward Yu took note of the facts – nearly 2 million deaths each year, 9 million infected each year, developments of multidrug-resistant, extensively drug-resistant and now totally ...

Ting-Wan Lin, Melrose M. Melgar, Daniel Kurth, S. Joshua Swamidass, John Purdon, Teresa Tseng, Gabriela Gago, Pierre Baldi, Hugo Gramajo, Shiou-Chuan Tsai Proceedings of the National Academy of ...

Isocitrate lyase (ICL) plays a pivotal role in the persistence of Mycobacterium tuberculosis in mice by sustaining intracellular infection in inflammatory macrophages. The enzyme allows net carbon ...