The immune system acts as a critical sentinel of organismal aging, integrating the sensing of physiological states with the ...

Aging is a complex biological process characterized by the progressive decline of physiological integrity, leading to impaired function and increased vulnerability to disease. It is the strongest risk ...

Senescence is a process in which a cell ages and stops dividing but does not die. In keratinocytes, or skin cells, senescence is marked by depolarization of membrane potential (Vmem), the electrical ...

Senescence, a phenomenon in which cells cease to divide and grow, can be caused by everything from natural DNA damage to treatment with chemotherapy. However, several mechanisms allow for cells to ...

Cellular senescence is a state characterized by permanent cell-cycle arrest, increased expression of markers such as p16^INK4a and p21^CIP1/WAF1, elevated DNA damage signals (e.g., γ-H2AX) and a ...

For many people, living longer brings health challenges: Osteoporosis, diabetes, Alzheimer’s disease. And of course, zombie cells. The technical term is senescent cells. They’re damaged and unable to ...

UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the ...

Cellular senescence is a state where cells permanently stop dividing but remain metabolically active, often in response to stress or damage. Senescent cells are known to play a key role in wound ...

Natural Killer (NK) cells are vital immune defenders that target and destroy cancer cells. However, in aging and cancer patients, NK cells often become "senescent"—losing their effectiveness due to ...