BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.

Stress granules are an integral part of the stress response that are formed from non-translating mRNAs aggregated with proteins. While much is known about stress granules, the factors that drive their ...

Since addressing the COVID-19 pandemic, mRNA vaccines have risen as a promising tool for treating a broad range of diseases, such as cancer and genetic disorders. To be effective, foreign mRNA in ...

Cell-to-cell communication is fundamental to all stages of life, and researchers have long studied its various mechanisms. In ...

During the oocyte-to-embryo transition (OET), the length of the mRNA poly(A) tail is closely linked to its translational efficiency. Regulation of the poly(A) tail is essential for selective protein ...

A team of researchers has uncovered a key cellular mechanism that affects the function of mRNA vaccines and therapeutics. Their study provides the first comprehensive understanding of how mRNA ...

In a recent study posted to the bioRxiv* preprint server, researchers reported severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein and S messenger ribonucleic acid (mRNA) ...

A team of researchers led by Dr. Kim V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of ...

Genome-wide CRISPR knockout screens to identify cellular regulators of LNP-based mRNA vaccines. mRNAs encoding Green Fluorescent Protein (GFP) were in vitro transcribed (IVT) and delivered to knockout ...