Site Interview (1) How was this issue identified? Starting in quarter 1 2007, we noticed the high rate of excess dosing for heparin on our ACTION site reports compared to national rates.

Feb 21, 2013 · Initial laboratory testing was within normal limits except for a prolonged activated partial thromboplastin time (aPTT) of 51 seconds (reference range, 23-29 seconds) and thrombocytopenia ...

Feb 21, 2013 · An important early step in evaluating a patient with an isolated prolonged aPTT is acquiring a good medical history, which will guide cost-effective laboratory testing.

Jan 28, 2013 · More appropriate assays for dabigatran may be activated partial thromboplastin time (aPTT), diluted thrombin time (TT), or ecarin clotting time (ECT).

Jul 31, 2007 · Heparin anticoagulation therapy requires careful dosing and monitoring to reduce the risk for patient harm and to maximize the therapeutic benefit.

The dilemma of whether to use a new therapeutic aPTT range or start monitoring intravenous UFH using the anti-Xa HA was debated.

A range of 1.5–2.5 times control values for the aPTT is considered therapeutic in the treatment of venous thromboembolic disease, based on a rabbit model of thrombosis [14] and early clinical ...

Jan 1, 2014 · The primary outcome, the percentage of patients whose aPTT values were within the therapeutic range at 6, 12, 24, 48, 72, and 96 hours, is presented in Table 4 .

Jan 1, 2014 · In our study, 88.3% of patients whose dosing was determined with the standard nomogram and 76.5% of those treated in accordance with the hepatic/critically ill nomogram …

Background: Both the activated partial thromboplastin time (aPTT) and anti-Xa assay can be used to monitor unfractionated heparin (UFH). Following implementation of an anti-Xa method for heparin ...